The FDA never legally approved this drug combo but that did not stop physicians from prescribing it. Numerous physicians benefited by selling the drugs together and this combination was regarded to be an effective, off-label medication.
Phentermine was also used in tandem with dexfenfluramine , the Dexfen-Phen combination. Dexfenfluramine was approved by the FDA in as an appetite suppressant and its union with phentermine became an overnight sensation. However, the rails began to fall off as this wonder combination was found to have induced negative side effects in its users.
In , the authors of a report published in the New England Journal of Medicine NEJM suggested a link between sustained use of these anorectic agents and mitral valve dysfunction, which is basically a heart valve disease.
The paper estimated that in the Fen-Phen combination had been prescribed to nearly 20 million people. A year-old woman, who had been using the Fen-Phen for a month, developed heart complications in and passed away shortly after. The Boston Herald published a front page article in her memory in the aftermath of her death in February , lambasting the drugs responsible for her death.
Multiple patients filed grievance reports at this time, citing the ill effects of Dexfen-Phen and Fen-Phen on their bodies. People all over the country were reporting side effects on a daily basis, putting pressure on the FDA and American Home Products. Patients, who had consumed only fenfluramine and dexfenfluramine, without combining them with phentermine, were also reporting side effects.
The Mayo Clinic had reported twenty four separate cases of heart valve disease by the summer of , all linked to the various combinations of phentermine.
The FDA could no longer sit idle and by September , it requested drug manufacturers to withdraw fenfluramine and dexfenfluramine from the market. Michael Friedman, who was the FDA's Lead Deputy Commissioner at the time, sent out a press release, publicly condemning fenfluramine and dexfenfluramine. However, phentermine received a stay of execution and continued to be commercially available. What exactly is phentermine and how does it work?
Phentermine is a substituted amphetamine based on the amphetamine structure. It is chemically and pharmacologically similar to the other types of drugs that have used as obesity treatment over the years. Phentermine and other drugs of this type are considered to be anorexigenics or anorectics. It is also pharmacologically similar to substances such as methamphetamine crystal meth , MDMA, ephedrine, and amphetamine itself. The substance is a psychostimulant drug and it possesses hallucinogenic properties.
As all amphetamine-based substances are considered to be controlled substances, phentermine is classified as a Schedule IV controlled substance because it apparently possesses a high potential for abuse. The drug should always be taken with extreme precaution and users must never take multiple doses of phentermine as it can be as addictive as crystal methamphetamine and ecstasy.
The chemical name of phentermine is 1,1-Dimethylphenylethylamine. It is a synthetic organic compound. The chemical formula of phentermine is C10H15N. The molecular weight of synthesized phentermine is Phentermine is a psychostimulant as it stimulates the central nervous system and elevates blood pressure.
This is how it functions as an appetite suppressant. Phentermine is a substance that causes neurons to expunge or maintain levels of a group of neurotransmitters that are called catecholamines. Dopamine and norepinephrine are a part of this group.
The drug appears to inhibit reuptake of these neurotransmitters by inhibiting or reversing the reuptake transporters. The drug also inhibits MAO enzymes, which causes a greater amount of neurotransmitters to remain at the synapse.
By elevating these catecholamines, experts hypothesize that the drug may have an impact on the brain's leptin levels. Phentermine is believed to raise the brain's leptin levels. The elevation of catecholamines is also believed to halt the chemical messenger neuropeptide Y, a peptide responsible for increasing hunger and fat storage.
Phentermine primarily works to reduce obesity by reducing the body's hunger perception. This is mainly done through a cognitive process by working on several nuclei in the hypothalamus section of the brain. The drug also works outside the brain by releasing adrenaline and noradrenaline to ensure that fat cells break down stored fat in the body.
Ideally, phentermine should be consumed in the morning an hour or two before the first meal of the day. Never consume phentermine in the evening or especially after a meal. Patients are advised to not consume phentermine in the evening due to the possibility of insomnia. Phentermine is normally available orally. It is available in orally dissolving capsules and tablets in a wide range of strengths, often based on the brand. Consumption of phentermine by any other form is ill advised.
Suprenza is an example of an orally disintegrating form of phentermine. Patients who consume suprenza must allow the drug to simply dissolve on their tongues. Different brands or labels of phentermine have different administration periods.
Most brands require you to take the drug before breakfast on an empty stomach, while there are some brands that recommend consumption between breakfast and lunch.
Never consume phentermine or any of its combinations in tandem with alcohol as the side effects of the drug is likely be extra harmful when the body is forced to break down alcohol and phentermine together. You should avoid any medication that has the potential to dull the nervous system, like alcohol does, when taking phentermine.
As phentermine stimulates the nervous system and alcohol inhibits it, the two work to cancel each other out and prevent the desired effects of phentermine from bearing fruit.
This is in fact a bigger problem with alcohol consumption than any possible side effects. If you are being administered monoamine oxidase inhibitors, do not, under any circumstances, consume phentermine concurrently. Patients should wait for a period of 14 days after completing their consumption of monoamine oxidase inhibitors to begin their consumption of phentermine.
If you find yourself developing a tolerance for your phentermine medication , do not start exceeding your recommended dosage. Instead, you should stop consuming phentermine and ask your physician to prescribe another weight loss drug. Alternatively, you can stop using phentermine for a couple of months which should remove your tolerance for the anorectic.
Despite the fact that phentermine in its current forms has no minimum administration period, the medication should ideally not be taken for more than weeks at a stretch as it can lead to serious long-term consequences if it's present in the body for a lengthy period of time. When you are using phentermine, make sure that you store the drug at room temperature.
Keeping it away from heat and moisture is of utmost importance. People who engage in potentially dangerous activities on a daily basis such as operating heavy machinery must take extra caution. If you are suffering from diabetes mellitus and taking medication, it is advisable to reduce the level of your oral hypoglycemic or insulin medication in a controlled manner before starting your course of phentermine.
Experts specify that certain types of people should not be prescribed phentermine because of its contraindication properties. Specifically, its use can be contraindicated in people who have glaucoma, a history of drug abuse, hyperthyroidism, a history of cardiovascular disease, and hypersensitivity. Individuals who are currently taking another form of amphetamine medicine such as adderall are also advised against consuming phentermine.
Pregnant women, women who are planning on becoming pregnant or those who are breast-feeding are also discouraged from using phentermine. This is because phentermine will pass through the breast milk of a woman who is breast feeding and directly to her baby. The effects of phentermine on small children are unknown as there have been almost no instances of such cases, but it is highly reasonable to assume that it will not end well for babies.
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So today will be a full month of me taking the product, I like to be completely thorough when leaving a review so people can have a better idea of what they are getting into. So some people claim they get 'jitters' from pills like these because of the caffeine, but I have never experienced this from any form of diet pill, I may just have a higher tolerance for caffeine? But I even doubled, the dose a couple times and had no ill effects. It would give me the boost I needed to go do a workout, or go for a walk, and it just made me FEEL better Adipex, is undeniably one of the top brands for weight loss that can be used for short term treatment of obesity.
Adipex weight loss pills can stimulate the sympathetic nervous system in order to promote suppression of appetite. Adipex is effective for losing weight especially if it is used together with a diet plan and regular exercise. Buy Direct and Save! Adipex is also referred to as Adipex-P which is a brand name for Phentermine. These are all the same drugs and do not have any differences in strength and composition. The Adipex diet pill is the top weight loss pill that can promote weight loss for a short term treatment.
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